Before taking Penegra 100 mg or any medication for erectile dysfunction, it's important to consult a healthcare provider, especially if you have underlying health conditions or are taking other medications. Penegra should not be taken with certain medications, particularly those containing nitrates, as this can lead to a dangerous drop in blood pressure. Additionally, alcohol consumption should be moderated, as excessive alcohol intake can interfere with the effectiveness of the medication and increase the risk of side effects.