Tadalista 20 generally starts to take effect within about 30 minutes to 1 hour after ingestion. As with other PDE5 inhibitors, sexual stimulation is necessary for the medication to be effective. Before using Tadalista 20 or any other ED medication, it's important to consult with a healthcare professional. They will assess your medical history, current medications, and overall health to determine if the medication is suitable for you. Some individuals may experience side effects or interactions with other drugs, so professional guidance is essential.